When it comes to tracking down the best vertical mouse for you in 2020, we’re here to help – minimise stress to muscles and tendons, and lower the risk of having issues such as RSI and carpal tunnel syndrome, with one of these fine gadgets.

If you want our advice, don’t wait it until you’re actually suffering to upgrade to one of the best vertical mouse models for Mac or Windows. Your hands will feel the benefit of the ergonomic design and natural, relaxed position (with the thumb up) right from the off.

Moving to a ‘handshake position’ mouse is a decision we don’t think you’re going to regret. Our carefully curated buyers guide features models of different shape, size, design and price but they all enable you to work, surf and game as before – just in a healthier way.

10. Autley Ergonomic Wireless Vertical Mice

The Autley Ergonomic Wireless offers an 80-degree angle to put your hand in as comfortable a position as possible. It tops out at a sensitivity of 1,600 DPI, though, which is probably fine for most people, but not ideal for gamers.

  • Works up to 33 feet away
  • Storage slot for usb receiver
  • Forward button performs poorly

9. Delux Adjustable 6-Button Vertical Mice

The Delux Adjustable 6-Button comes with a removable wrist rest, which can be a huge help if the height between your chair and desk is never quite right. Its DPI switch is located on the bottom, so you won’t accidentally hit it.

  • Works on a variety of surfaces
  • High-gloss finish
  • Side buttons struggle with macs

8. Jelly Comb Optical Vertical Mice

The Jelly Comb Optical is smaller than a lot of other options in this category, making it a good choice for those with slight hands. It has a blue LED that glows when it’s plugged in and turns red when its battery gets low.

  • Operates with a quiet click
  • Stays connected reliably
  • Charging port is poorly designed

7. Delux Ergonomic Silent Vertical Mice

The Delux Ergonomic Silent can connect to your computer using a 2.4-gigahertz, USB radio dongle or via Bluetooth. That means you can use it with two different devices, moving back and forth with a simple flip of its switch.

  • Available in three colors
  • Clicks are extremely quiet
  • Build quality is a bit cheap

6. Zlot Rechargeable Vertical Mice

The Zlot Rechargeable plugs into your computer’s USB port, eliminating the need for costly batteries. It sports a blue LED light running along its base, and is equipped with convenient forward and back buttons for browsing the web, though these do not work with Mac OS X.

  • Six navigation buttons
  • Ten-meter transmission range
  • Weighs just 130 grams

5. Anker Ergonomic Vertical Mice

The Anker Ergonomic places its back and forward navigation buttons next to your thumb, making web browsing both fast and easy. It’s compatible with Windows, Mac, and Linux operating systems, and the included USB cable is nearly five feet long.

  • Accurate optical tracking
  • 18-month warranty
  • Only two sensitivity levels

4. Kinesis DXT2 Vertical Mice

Rather than wrapping your palm around it, the Kinesis DXT2 is designed to be held by just your thumb and fingertips, and is one of the smallest options out there. It offers four sensitivity levels between 500 and 2,000 DPI.

  • Good for lefties and righties
  • Also available as a wired model
  • Coating wears away over time

3. Logitech Wireless MX Advanced Vertical Mice

The Logitech Wireless MX Advanced sits at a comfortable 57-degree angle, and offers nuanced tracking at up to 4,000 DPI. That can reduce the amount of movement necessary by 400 percent, cutting down on wrist and hand strain further.

  • Lasts four months on a full charge
  • Textured thumb rest
  • Back and forward buttons on the side

2. Jelly Comb Bluetooth Vertical Mice

The Jelly Comb Bluetooth is equipped with three DPI options that top out at 2,400, so it is a viable option for graphic artists and even some gamers. Its concave thumb rest makes it one of the most comfortable models in thew category.

  • Rated for 3 million clicks
  • Runs on a single aa battery
  • One-year warranty

1. Posturite Wired Penguin Vertical Mice

The Posturite Wired Penguin is symmetrical, making it comfortable for both right- and left-handed people. Its trigger-style button layout is more intuitive than many options and simple to operate, as well, and it tracks accurately on most surfaces.

  • Wide base for stability
  • Good fit for large hands
  • Scroll wheel provides smooth motion


The first rule of fight club is: if you’re spending countless hours on your computer every day and wrist pain has become the new normal (think along the lines of repetitive strain injuries), you must go buy a vertical mouse ASAP. Here’s what to look after in a high-quality vertical mouse: first, there’s the ergonomic index thing. Basically, you can simply look for the highest one available and ignore literally everything else. However, this may not work, because we don’t have (yet) an objective standard with regard to ergonomicness (yes, I’ve just made up that word); as in, different things work for different people, and that’s the rule of the land since like forever.

Vertical mice are designed to reduce wrist movement, as bending your wrist also bends the channels through which your nerves run. That’s why people with carpal tunnel syndrome wear braces by the way, and vertical mice are designed to be literal braces for your wrist, i.e. they help with keeping it straight. Consider whatever vertical mouse of your liking, and if it’s shaped correctly and large enough for your hands, it should fit the bill. Ideally speaking, a “test drive” would be great before going on a buying spree.

Obviously, that would require a visit to your local brick-and-mortar store that sells computer peripherals (Walmart, Staples or whatever); if you’re too lazy for that, don’t worry, you can buy it online and return it if you’re not happy with your “blind date”. When it comes to mice, there’s always the wired vs wireless mouse conundrum, and after all’s said and done, it’s up to you to decide what you want, as the differences in overall performance are minimal between the two varieties.

Since vertical mice are not the best option for gaming, precision/latency and things of that nature are not a real issue. The same goes for optical vs laser sensors, as most people are incapable of noticing any difference between the two. Now, if you’re working in a “high precision environment”, i.e. if you’re a designer or a graphic artist, check out the DPI thing just in case and remember that laser mice work great anywhere, while optical sensors prefer non-glossy surfaces. Finally, look at the number of programmable buttons, provided you require such a thing and let’s move on to the meat of the story and take a look at the best vertical mice as per today.